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A rare association of Castleman′s disease and nephrotic syndrome
Tazi I,Rachid M,Quessar A,Benchekroun S
Saudi Journal of Kidney Diseases and Transplantation , 2011,
Abstract: Castleman′s Disease (CD) is an uncommon and poorly understood disorder of lymph node hyperplasia of unknown etiology. This entity belongs to the atypical lymphoproliferative disorders, a heterogeneous group of diseases characterized by a hyperplastic reactive process involving the immune system. The association of the nephrotic syndrome and CD is extremely rare and their interrelation remains enigmatic. We report a case of CD of the hyaline-vascular type with unicentric localization complicated by nephrotic syndrome.
Imagerie des fistules arterio-veineuses durales a drainage veineux peri -medullaire
A Melhaoui, A El Quessar, M El Hassani, N Chakir, M Jiddane
African Journal of Neurological Sciences , 2008,
Abstract: Les fistules durales rachidiennes à drainage veineux périmédullaire constituent une pathologie d’individualisation récente. C’est les plus fréquentes des malformations vasculaires vertébromédullaires, elles se présentent sous la forme d’une myélopathie spastique progressive chez un sujet de plus de 40 ans. A partir d’une étude rétrospective des données cliniques et explorations radiologiques d’une série de 11 cas en IRM et artériographie médullaire, nous avons recensé l’ensemble des signes radiologiques qui orientent le diagnostic. L’IRM a montré un hypersignal T2 centromédullaire de fa on constante ainsi que des vaisseaux périmédullaires pathologiques. L’angiographie médullaire reste l’examen clé pour le diagnostic. Elle a permit de montrer dans dix cas le shunt artério-veineux ainsi que ses afférences artériels et son retour veineux, permettant de planifier le traitement. Huit patients ont été pris en charge chirurgicalement avec exclusion de la fistule suivie d’une amélioration clinique. L’imagerie joue aussi un r le important dans le suivi postthérapeutique. L’IRM permet de mettre en évidence la disparition progressive des anomalies initiales, signe de l’efficacité du traitement. Les fistules artério-veineuses à drainage veineux périmédullaire sont une pathologie qui reste encore méconnue. La connaissance de tous ces éléments d’imagerie est fondamentale pour un diagnostic et une prise en charge précoces, seuls garants d’une bonne évolution après traitement.
FLT3-ITD Incidence and FLT-D835 Mutations in Acute Myeloid Leukemia Patients with Normal Karyotype in Morocco: A Preliminary Study
Hind Dehbi,Yaya Kassogue,Sanaa Nasserddine,Asma Quessar
Middle East Journal of Cancer , 2013,
Abstract: Background: According to numerous studies, FMS-like tyrosine kinase 3, internal tandem duplication, and the D835 mutation are associated with a poor prognostic clinical outcome in acute myeloid leukemia patients. Detection of the FMS-like tyrosine kinase 3 mutation in patients who present with normal karyotype acute myeloid leukemia helps in both the understanding of the disease and the treatment of patients. This study evaluates the incidence of FMS-like tyrosine kinase 3-internal tandem duplication and FMS-like tyrosine kinase 3-D835 mutation in newly diagnosed patients with normal karyotype acute myeloid leukemia.Methods: This study looked at 33 new cases who presented with normal karyotype acute myeloid leukemia at diagnosis. We collected peripheral blood samples from patients at diagnosis. FMS-like tyrosine kinase 3-internal tandem duplication mutation was detected using polymerase chain reaction and FMS-like tyrosine kinase 3-D835 mutation by restriction fragment length polymorphism after polymerase chain reaction.Results: FMS-like tyrosine kinase 3-internal tandem duplication mutation was found in 18% (6/33) of all patients and in 30% (6/20) of patients over 30 years of age. FMSlike tyrosine kinase 3-internal tandem duplication mutation was most common with M2 (50%), M5 (33.3%), and M0 (16.7%). FMS-like tyrosine kinase 3-D835 mutation was detected in one patient (3%) that had M2. No significant association was found between FMS-like tyrosine kinase 3 mutation and age, sex, white blood cell count, platelets, or blasts percentage.Conclusion: Most of FMS-like tyrosine kinase 3 mutations were found in patients older than 30 years. The frequency observed in this work is comparable with that observed in the literature. No pediatric case of FMS-like tyrosine kinase 3 mutation was found in this study. A large scale study is needed to confirm our findings and to further appreciate the prognostic value of FMS-like tyrosine kinase 3 mutation among Moroccan patients.
Vertebral Hemangiomas - Aggressive Forms
Nazik Allali, Moulay Rachid, My R El Hassani, Abdeljalil El Quessar, Nourradine Chakir, Mohammed Jiddane
African Journal of Neurological Sciences , 2002,
Abstract: Les Hemangiomes Vertebraux Agressifs (Francais) Résumé Introduction Les hémangiomes vertébraux sont des tumeurs bénignes généralement asymptomatiques. Les tumeurs agressives représentent moins de 1% des cas. L\'imagerie permet de poser le diagnostic positif et le degré d\'agressivité. Objectif Evaluer le r le des examens radiographiques et des moyens thérapeutiques, embolisation, chirurgie, vertébroplastie, radiothérapie en présence d\'un hémangiome vertébral. Méthodes Il s\'agit d\'une étude rétrospective de 5 patients dont l\'age moyen était de 20 ans. La symptomatologie clinique était celle d\'une compression médullaire d\'installation progressive dans tous les cas. Les radiographies standards, la TDM et l\'IRM sont réalisées chez tous les patients. Résultats Les hémangiomes vertébraux étaient localisés au niveau du rachis cervical C4 dans un cas et dorsal (D3-D9) dans 4 cas. La radiographie standard a montré un aspect classique de vertèbre grillagée. L\'IRM a objectivé un aspect hétérogène des vertèbres atteintes avec des zones vides de signal d\'aspect serpigineux et des zones d\'hyper signal et d\'iso signal en Tl aug - mentant en T2. la composante épidurale responsable de la compression médullaire présente les mêmes caractéristiques de signal que la lésion vertébrale. Devant cet aspect 2 patients ont bénéficié d\'une embolisation préopératoire. Conclusion Le diagnostic des hémaniomes vertébraux agressifs est aisé grace à l\'imagerie par l\'analyse de l\'architecture lésionnelle et de l\'étendue épidurale. Elles permettent d\'établir un score d\'agressivité qui oriente l\'attitude thérapeutique. La conduite thérapeutique qui nous semble la mieux adaptée devant ces hémangiomes agressifs reste l\'association d\'une embolisation avec une vertébroplastie percutanée associée éventuellement à une chirurgie en cas d\'atteinte épidurale. Background Vertebral hemangiomas are benign tumours and are rarely symptomatic. Aggressive forms represent less than 1% of all cases. Medical imaging allows both diagnosis and evaluation of their aggressivity. Objective To assess the role of radiology, embolisation, percutaneous vertebroplasty, radiotherapy and surgery in the diagnosis and treatment of vertebral hemangiomas. Methods We report our experience of five patients who had an average age of 20 years. They all presented with progressive medullary compression and were investigated with plain xrays, CT and MRI. Results The vertebral hemangiomas were located in the cervical spine at C4 in one patient and between D3 and D9 in the other four. Plain xrays showed the classic vertical striations and MRI revealed a heterogeneous picture with attenuation of signal in some and hyper or iso intense signals on T1 and hyper intense T2 in the others. The epidural component presented the same imaging characteristics as the bony lesions. Two of our patients were embolised before surgery. Conclusion Analysis of the radiological and imaging characteristics of these lesions m
Massive Thrombosis of the Right Atrium Extended to the Superior Vena Cava at the Diagnosis of Acute Myeloid Leukemia
Asmaa Quessar,Bienvenu Houssou,Gnon Gourou Orou-Guiwa,Meryem Qachouh,Rachida Habbal
- , 2016, DOI: 10.1155/2016/6802429
Abstract:
Recurrent Transient Ischemic Attacks Revealing Cerebral Amyloid Angiopathy: A Comprehensive Case  [PDF]
Kenza Khelfaoui Tredano, Houyam Tibar, Kaoutar El Alaoui Taoussi, Wafae Regragui, Abdeljalil El Quessar, Ali Benomar
World Journal of Neuroscience (WJNS) , 2024, DOI: 10.4236/wjns.2024.141004
Abstract: This case report investigates the manifestation of cerebral amyloid angiopathy (CAA) through recurrent Transient Ischemic Attacks (TIAs) in an 82-year-old patient. Despite initial diagnostic complexities, cerebral angiography-MRI revealed features indicative of CAA. Symptomatic treatment resulted in improvement, but the patient later developed a fatal hematoma. The discussion navigates the intricate therapeutic landscape of repetitive TIAs in the elderly with cardiovascular risk factors, emphasizing the pivotal role of cerebral MRI and meticulous bleeding risk management. The conclusion stresses the importance of incorporating SWI sequences, specifically when suspecting a cardioembolic TIA, as a diagnostic measure to explore and exclude CAA in the differential diagnosis. This case report provides valuable insights into these challenges, highlighting the need to consider CAA in relevant cases.
Cost of Treatment of Cerebral Aneurysm Embolization: Study of Associated Factors
Aasfara Jehanne,Ababou Adil,Amine Cheikh,Benomar Ali,El Hassani Amine,El Quessar Abdeljalil,Razine Rachid,Yahya Cherrah
- , 2016, DOI: 10.1007/s40120-016-0044-6
Abstract: Surgical clipping or endovascular coiling are the main procedures used in the treatment of cerebral aneurysms, with a preference for endovascular coiling. In Morocco, the number of patients needing endovascular coiling is growing, but many of them do not have access to this technique. The aim of this study was to determine the main parameters associated with variations in the total cost of this procedure in order to establish the amount (lump sum) that may be reimbursed by health insurance funds
An autosomal recessive leucoencephalopathy with ischemic stroke, dysmorphic syndrome and retinitis pigmentosa maps to chromosome 17q24.2-25.3
Ahmed Bouhouche, Ali Benomar, Leila Errguig, Lamiae Lachhab, Naima Bouslam, Jehanne Aasfara, Sanaa Sefiani, Layachi Chabraoui, Elmostafa El Fahime, Abdeljalil El Quessar, Mohamed Jiddane, Mohamed Yahyaoui
BMC Medical Genetics , 2012, DOI: 10.1186/1471-2350-13-18
Abstract: All family members underwent neurological and radiological examinations. A genome wide search was conducted in this family using the ABI PRISM linkage mapping set version 2.5 from Applied Biosystems. Six candidate genes within the region linked to the disease were screened for mutations by direct sequencing.Evidence of linkage was obtained on chromosome 17q24.2-25.3. Analysis of recombination events and LOD score calculation suggests linkage of the responsible gene in a genetic interval of 11 Mb located between D17S789 and D17S1806 with a maximal multipoint LOD score of 2.90. Sequencing of seven candidate genes in this locus, ATP5H, FDXR, SLC25A19, MCT8, CYGB, KCNJ16 and GRIN2C, identified three missense mutations in the FDXR gene which were also found in a homozygous state in three healthy controls, suggesting that these variants are not disease-causing mutations in the family.A novel locus for leucoencephalopathy with ischemic stroke, dysmorphic syndrome and retinitis pigmentosa has been mapped to chromosome 17q24.2-25.3 in a consanguineous Moroccan family.Nuclear single-gene disorders related to ischemic stroke are an important cause of stroke, especially in young patients without known risk factors [1]. These diseases could be associated with different stroke phenotypes including arterial dissection, small vessel, and large vessel which are inherited as dominant, recessive or X linked trait. Up to date, 4 loci have been described for the autosomal dominant form. Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) which is a generalized disease of the small arteries, largely predominating in the brain caused by mutations in NOTCH3 gene [2,3]. Hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS) is a rare multisystemic disease presenting with leukoencephalopathy, progressive visual loss and nephropathy due to mutations in the TREX1 gene [4]. Marfan syndrome (MFS) which is a connective tissue
The Spread of Infectious Disease on Network Using Neutrosophic Algebraic Structure  [PDF]
A. Zubairu, A. A. Ibrahim
Open Journal of Discrete Mathematics (OJDM) , 2017, DOI: 10.4236/ojdm.2017.72009
Abstract: Network theory and its associated techniques has tremendous impact in various discipline and research, from computer, engineering, architecture, humanities, social science to system biology. However in recent years epidemiology can be said to utilizes these potentials of network theory more than any other discipline. Graph which has been considered as the processor in network theory has a close relationship with epidemiology that dated as far back as early 1900 [1]. This is because the earliest models of infectious disease transfer were in a form of compartment which defines a graph even though adequate knowledge of mathematical computation and mechanistic behavior is scarce. This paper introduces a new type of disease propagation on network utilizing the potentials of neutrosophic algebraic group structures and graph theory.
A Comparative Investigation of Lead Sulfate and Lead Oxide Sulfate Study of Morphology and Thermal Decomposition  [PDF]
S. A. A. Sajadi
American Journal of Analytical Chemistry (AJAC) , 2011, DOI: 10.4236/ajac.2011.22024
Abstract: The compound lead oxide sulfate PbSO4.PbO was prepared in our laboratory. The Thermal behavior of PbSO4 was studied using techniques of Thermogravimetry under air atmosphere from 25 to 1200°C. The identity of both compounds was confirmed by XRD technique. Results obtained using both techniques support same decomposition stages for this compound. The electron microscopic investigations are made by SEM and TEM. The compound is characterized by XRD and the purity was determined by analytical Methods. Also a series of thermogravimetric analysis is made and the ideal condition is determined to convert this compound to pure lead oxide.
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